TRODAT-1 and Tc-99m ECD observations in hyperglycemia hemichorea
- Author:
in-Chien Tu
;
Ching-Yuan Chen
;
Chung-Ping Lo
;
Chi-Chung Kuo
- Publication Type:Case Reports
- MeSH:
Hyperglycemia
- From:Neurology Asia
2016;21(1):85-87
- CountryMalaysia
- Language:English
-
Abstract:
We describe two cases of right hyperglycemia hemichorea (HGHC) with identical Tc-99m TRODAT-1/
Tc-99m ECD scan findings. While the brain MRI showed signal alterations within the left putamen,
there was evidence of hyperperfusion on Tc-99m TRODAT-1 but hypoperfusion on Tc-99m ECD
within the left putamen, in association with hyperperfusion within left thalamus on Tc-99m ECD.
The discrepancy between the Tc-99m TRODAT-1 and Tc-99m ECD scan provides insight into the
imbalance between direct and indirect circuits along the nigrostriatal pathway, as the fundamental
genesis of HGHC. Furthermore, the hyperperfusion at the left thalamus represents thalamic disinhibition
secondary to loss of pallidal negative control, which ultimately leads to HGHC through re-entrant
outflow to the motor cortex.
- Full text:P020160405356389104758.pdf
