Identifying the injury in demyelinating cervical spinal cord disease: A diffusion tensor imaging and tractography study
- Author:
Jiafeng Chen
;
Chunkui Zhou
;
Lijun Zhu
;
Xin Chen
;
Shaokuan Fang
;
Jiafeng Chen
;
Chunkui Zhou
- Publication Type:Journal Article
- MeSH:
Spinal Cord Diseases
- From:Neurology Asia
2016;21(1):73-80
- CountryMalaysia
- Language:English
-
Abstract:
Background & Objectives: Multiple sclerosis (MS), neuromyelitis optica (NMO) and acute transverse
myelitis (ATM) are common diseases in neurology; however their corresponding cervical spinal
cord involvements are still ambiguous. The purpose of this study was to demonstrate the utility of
diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) in identifying the injury in
cervical spinal cord. Methods: Nine patients and nine healthy volunteers were enrolled in this study.
Conventional sequences and DTI scan were performed on each participant. Results: The average
fractional anisotrophy (FA) values of the cervical cord in patients with acute cerebral type MS, acute or
stationary cerebrospinal type MS, acute NMO, or acute ATM were all significantly decreased relative
to the control group (p <0.05). As to the cerebrospinal type MS, the changes in acute-stage patients
were more apparent (p <0.05). The average FA value of the cervical cord in acute NMO was decreased
more extensively, involving the normal-appearing spinal cord (p <0.05). In patients with MS or NMO,
The lesions showed significantly hypointense on FA images and directionally encoded color (DEC)
images, nevertheless the pathological areas on DTI images were no significantly different from those
on routine sequences. On DTT, the fiber tracts in the lesion-involved regions were all sparser than
that in control regions, nevertheless interruption or impairment of fiber tracts could only be noted in
NMO patients. Bilateral differences of average FA values in the cervical cord was noted in one case
with ATM and another case with MS (p <0.05), and the decrease of FA values was significant in the
main side of clinical presentations.
Conclusion: DTI and DTT may be a sensitive measure for early cervical injury in MS, NMO and ATM
- Full text:P020160405347390678076.pdf
