Non-motor symptoms in Thai Parkinson’s disease patients and the correlation with motor symptoms
- Author:
Pawut Mekawichai
;
Salintip Kunadisorn
;
Chaiwiwat Tungkasereerak
;
Surin Saetang
- Publication Type:Journal Article
- MeSH:
Parkinson Disease
- From:Neurology Asia
2016;21(1):41-46
- CountryMalaysia
- Language:English
-
Abstract:
Background and objective:to identify the prevalence of non-motor symptoms (NMS) and to determine the
association between NMS and motor symptoms in Thai Parkinson’s disease (PD) patients. Methods: A cross
sectional study was performed in PD patients at Maharat Nakhon Ratchasima Hospital between January-June
2014. The NMS were assessed by using Non-Motor Symptoms Questionnaire-Thai version. All data were
analyzedfor identifying the prevalence of NMS and determining the correlation between NMS and motor
symptoms. Results:One hundred thirty six PD patients were enrolled. The severity of disease according to
Modified Hoehn and Yahr (MHY) was 1-1.5=33.1% of the patients, 2-2.5=52.2% and 3-5=14.7%. All patients
(100%) had NMS with mean number of 13.2±6.7 symptoms (ranging from 1-29). Nocturia was the commonest
symptom (82.4%), followed by constipation (74.3%) and forgetfulness (69.9%). Bowel incontinence was
the least frequent symptom (19.9%). Sleep disorder was the mostprevalent domain (92.6%), followed by
digestive domain (91.9%) and urinary domain (89.0%). The number of NMS significantly increased with
the degree of severity of disease and was higher in patients with motor complications.
Conclusion:NMS were reported by every Thai PD patients, and at all stage of the disease. Nocturia symptom
and sleep disorder domain were the most frequent NMS. The number of NMS strongly correlated with
motor complications and the severity of motor symptoms. However the presence of motor complications
appears to have stronger association with some NMS domains than the motor severity
- Full text:P020160405328992072964.pdf
