Exercise attenuates oxidative stress in patients with stroke
- Author:
Nagatoshi Kihoin
;
Kazunari Tanaka
;
Masaaki Okuno
;
Tadashi Okamoto
;
Ryuichi Saura
- Publication Type:Journal Article
- MeSH:
Oxidative Stress;
Stroke;
Arteriosclerosis
- From:Neurology Asia
2016;21(1):7-16
- CountryMalaysia
- Language:English
-
Abstract:
In stroke patients, excessive oxidative stress impairs brain nerve cells and leads to arteriosclerosis. On
the other hand, rehabilitative exercise is necessary for the functional improvement and maintenance
after stroke, and exercises themselves increase reactive oxygen species production simultaneously.
Therefore, it is essential to elucidate how exercises influence oxidative stress in stroke patients. We
assessed the effects of exercises on 29 Japanese subacute-phase stroke patients (exercise group, 20;
control group, 9), in terms of oxidative stress by examining changes in reactive oxygen metabolite
(ROM) level (i.e., oxidative stress) and biological antioxidant potential (BAP) level (i.e., antioxidant
capacity) in blood plasma. The exercise group performed two sets of 1-hour exercises 6 days/week for
56 days. The control group performed the same 1-hour exercises, but only on days 1 and 56. ROM and
BAP levels in blood plasma in both groups were measured immediately before and after the exercises
and at rest on days 1 and 56. ROM level significantly decreased and BAP level significantly increased
at rest from days 1 to 56 in the exercise group. However, no significant change was observed in these
levels in the control group.
Conclusion: Regular rehabilitative exercise can improve antioxidant capacity and attenuate oxidative
stress even in stroke patients.
- Full text:P020160404578008958842.pdf
