Changes in neuromedin S and its receptor after traumatic brain injury in cycling rats
- Author:
Mohammad Khaksari
;
Fatemeh Maghool
;
Gholamreza Asadikaram
;
Vida Naderi
- Publication Type:Review
- MeSH:
Neuropeptides;
Receptors, Neuropeptide
- From:Neurology Asia
2015;20(4):375-384
- CountryMalaysia
- Language:English
-
Abstract:
Animal studies indicate that gonadal steroids have prominent neuroprotective effects in several models
of experimental traumatic brain injury (TBI). Neuromedin U (NMU) and neuromedin S (NMS) are
regulatory peptides involved in inflammatory and stress responses, and modulation of the gonadotropic
axis. Since steroid hormone levels change during the estrous cycle, we sought to determine whether
variations in ovarian hormones would affect blood-brain barrier (BBB) permeability and brain levels
of NMS, NMU, and neuromedin S receptor 2 in experimental TBI. Two groups (proestrus and nonproestrus)
of female rats underwent diffuse TBI. At 24 hrs after TBI, results showed a significantly
decrease in BBB permeability in traumatic-proestrus animals (TBI-P) in comparison to traumatic nonproestrus
(TBI-NP) rats. Western blot analyzes demonstrated an enhanced expression of prepro-NMS
in TBI-P compared with that in the TBI-NP group. Likewise, TBI-P rats exhibited significantly higher
NMUR2 gene expression compared with those of TBI-NP, whereas no significant difference in brain
NMU content was seen between sham and traumatic animals. Our findings indicate that diffuse TBI
induces an increase in prepro-NMS and neuromedin S receptor 2 expression in traumatic-proestrus
rats which may mediate the anti-edematous effects of gonadal hormones in proestrus rats following
trauma.
- Full text:P020160302368908871680.pdf
