A mini review on the basic knowledge on tendon: revisiting the normal & injured tendon
- Author:
Tan SL
;
Selvaratnam L
;
Ahmad TS
- Publication Type:Review
- Keywords:
Cell based therapy;
cell differentiation;
expression profile;
orthopaedics;
stem cell biology;
tendon tissue engineering
- MeSH:
Tissue Engineering
- From:Journal of University of Malaya Medical Centre
2015;18(2):1-14
- CountryMalaysia
- Language:English
-
Abstract:
Tendon is a dense connective tissue that connects muscle to bone. Tendon can adapt to mechanical forces
passing across it, through a reciprocal relationship between its cellular components (tenocytes and tenoblasts)
and the extracellular matrix (ECM). In early development, the formation of scleraxis-expressing tendon
progenitor population in the sclerotome is induced by a fibroblast growth factor signal secreted by the myotome.
Tendon injury has been defined as a loss of cells or ECM caused by trauma. It represents a failure of cells
and matrix adaptation to mechanical loading. Injury initiates attempts of tendon to repair itself, which has
been defined as replacement of damaged or lost cells and ECM by new cells or new matrices. Tendon healing
generally consists of four different phases: the inflammatory, proliferation, differentiation and remodelling
phases. Clinically, tendons are repaired with a variety of surgical techniques, which show various degrees
of success. In order to improve the conventional tendon repair methods, current tendon tissue engineering
aims to investigate a repair method which can restore tissue defects with living cells, or cell based therapy.
Advances in tissue engineering techniques would potentially yield to a cell-based product that could regenerate
functional tendon tissue.
- Full text:P020160111584021370150.pdf
