Diagnostic Performance of Intravascular Ultrasound-Derived Minimal Lumen Area to Predict Functionally Significant Non-Left Main Coronary Artery Disease: a Meta-Analysis.
10.4070/kcj.2016.46.5.622
- Author:
Jae Sik JANG
1
;
Ho Cheol SHIN
;
Jong Seok BAE
;
Han Young JIN
;
Jeong Sook SEO
;
Tae Hyun YANG
;
Dae Kyeong KIM
;
Kyoung Im CHO
;
Bo Hyun KIM
;
Yong Hyun PARK
;
Hyung Gon JE
;
Dong Soo KIM
Author Information
1. Division of Cardiology, Busan Paik Hospital, University of Inje College of Medicine, Busan, Korea. jsjang71@gmail.com
- Publication Type:Meta-Analysis ; Original Article
- Keywords:
Intravascular ultrasonography;
Fractional flow reserve;
Percutaneous coronary intervention
- MeSH:
Coronary Artery Disease*;
Coronary Stenosis;
Coronary Vessels*;
Humans;
Odds Ratio;
Percutaneous Coronary Intervention;
ROC Curve;
Sensitivity and Specificity;
Stents;
Ultrasonography;
Ultrasonography, Interventional
- From:Korean Circulation Journal
2016;46(5):622-631
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention frequently results in unnecessary stenting due to the low positive predictive value of IVUS-derived minimal lumen area (MLA) for identification of functionally significant coronary stenosis. We appraised the diagnostic accuracy of IVUS-derived MLA compared with the fractional flow reserve (FFR) to assess intermediate coronary stenosis. SUBJECTS AND METHODS: We searched MEDLINE and Cochrane databases for studies using IVUS and FFR methods to establish the best MLA cut-off values to predict significant non-left main coronary artery stenosis. Summary estimates were obtained using a random-effects model. RESULTS: The 17 studies used in our analysis enrolled 3920 patients with 4267 lesions. The weighted overall mean MLA cut-off value was 2.58 mm². The pooled MLA sensitivity that predicted functionally significant coronary stenosis was 0.75 (confidence interval [CI]: 0.72 to 0.77) and the specificity was 0.66 (CI: 0.64 to 0.68). The positive likelihood ratio (LR) was 2.33 (CI: 2.06 to 2.63) and LR (-) was 0.33 (CI: 0.26 to 0.42). The pooled diagnostic odds ratio (DOR) was 7.53 (CI: 5.26 to 10.76) and the area under the summary receiver operating characteristic curve for all the trials was 0.782 with a Q point of 0.720. Meta-regression analysis demonstrated that an FFR cut-off point of 0.75 was associated with a four times higher diagnostic accuracy compared to that of 0.80 (relative DOR: 3.92; 95% CI: 1.25 to 12.34). CONCLUSION: IVUS-derived MLA has limited diagnostic accuracy and needs careful interpretation to correlate with functionally significant non-left main coronary artery stenosis.