Expression and clinical significance of anti-apoptosis gene survivin in breast cacer tissues

VernacularTitle:凋亡抑制基因survivin在乳腺癌组织的表达及其意义
Author: Yayuan WEN ; Zilin YE ; Zhenxiang YAO
Publication Type:Journal Article
Keywords: Breast cancer; Survivin; PR; ER; Her-2
From: Journal of Endocrine Surgery 2011;05(3):152-154,169
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of snrvivin,an anti-apoptosis gene,in breast cancer tissues and its relationship with clinical parameters of breast cancer patients.To investigate the role of survivin in oncogenesis of breast cancer and its relation with prognosis of breast cancer.Methods Western blot was conducted to detect survivin expression in cancerous tissues and adjacent tissues of 50 breast cancer patients.20 normal breast tissue samples were used as control.Results Survivin was expressed in 38 of the 50 breast cancer tissues (76.0%)and in 11 of 50 breast adjacent normal tissues(22.0%)while no expression was found in normal tissues.The positive protein expression of survivin was related to axillary lymph node metastasis of breast cancer while it was not related to expression of PR,ER,Her-2 or ages of patients.Conclusion Survivin may play a role in breast tumorigenesis and is an important predictive parameter in breast cancer patients.