Expression of ER, PR, HER-2, Ki-67 before and after neoadjuvant chemotherapy and the relation between their expression and the curative effects of neoadjuvant chemotherapy in breast cancer
10.3760/cma.j.issn.1674-6090.2012.05.004
- VernacularTitle:ER、PR、HER-2、Ki-67在乳腺癌新辅助化疗前后的改变及与疗效的关系
- Author:
Dongsong LI
;
Biao WU
;
Zhengren LIU
;
Yi SHU
;
Zhichun WANG
;
Qinglong HU
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Neoadjuvant chemotherapy;
ER;
PR;
HER-2;
Ki-67
- From:
Journal of Endocrine Surgery
2012;06(5):298-300,334
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the relationship between the expression of ER,PR,HER-2,Ki-67 and the effective rate of neoadjuvant chemotherapy (NAC) and to study the influence of NAC on expression of ER,PR,HER-2 and Ki-67 in breast cancer.Methods41 patients of breast cancer were performed 2 to 6 cycles of CAF chemotherapy.The expression of ER,PR,HER-2 and Ki-67 was detected by SP immunohistochemical method before and after NAC.ResultsThe effective rate of NAC was 73.17％ (30/41).The positive and negative efficiency rate was 67.86％ (19/28) vs 84.62％ ( 11/13 ) for ER,64.29％ (9/14) vs 77.78％ (21/27 ) for HER-2,70.00％ (14/20) vs 76.19％ ( 16/21 ) for Ki-67.The difference had no statistical significance (P ＞0.05).The positive and negative efficiency rate was 66.67％ (16/24) vs 82.35％ (14/17) for PR.The difference had statistical significance (P ＜ 0.05 ).The expression of ER,PR,HER-2 and Ki-67 before and after NAC changed in 10,8,3 and 9 cases respectively.The difference had no statistical significance (P ＞ 0.05).ConclusionsNAC has no influence on the expression of ER,PR,HER-2 and Ki-67.Patients with PR negative are more sensitive to NAC.The expression state of PR can be used to predict the curative effect of NAC.The expression state of ER,HER-2 and Ki-67 has no significant correlation with NAC.
