EXPRESSIONS OF P53, PROLIFERATING CELL NUCLEAR ANITIGEN, BCL-2 PROTEIN AND THEIR SIGNIFICANCE IN SALIVARY ADENOID CYSTIC CARCINOMA
- Author:
Yincheng ZHANG
;
Yanmei ZHU
;
Xiaoming JIN
- Publication Type:Journal Article
- Keywords:
adenoid cystic carcinoma (ACC);
P53 protein;
proliferating cell nuclear antigen (PCNA);
Bcl-2 protein
- From:
Journal of Pharmaceutical Analysis
2000;12(1):67-69,80
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of P53, PCNA, Bcl-2 protein and their relationship in salivary adenoid cystic carcinoma(SACC). Methods These proteins were examined by immunohistochemistry. Results Overexpressions of P53 and PCNA were revealed in ACC samples, they were higher than those in (polymorphous adenomas) PA, but expression of Bcl-2 protein was not different between ACC and PA. In 3 subtypes of ACC, expressions of 3 proteins were different. Conclusion Mutations of P53, Bcl-2 may be involed in the occurrence of SACC, expression of PCNA and mutation of P53 may coexist in the development of the SACC.
