THE EXPRESSION AND CLINICAL SIGNIFICANCE OF P21 (WAF1/CIP1)AND CYCLIN D1 PROTEIN IN COLORECTAL CARCINOMA
- Author:
Liahui LEI
;
Yanfa XU
;
Wei SHENG
- Publication Type:Journal Article
- Keywords:
colorectal carcinoma;
P21(WAF1/CIP1);
cyclin D1;
immunohistochemistry;
prognosis
- From:
Journal of Pharmaceutical Analysis
2000;12(2):160-162,167
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effect of P21 (WAF1/CIP1) and cyclin D1 and their relationship in colorec- tal carcinoma. Methods The expression of P21 and cyclin D1 was studied in 40 colorectal carcinoma and 10 normal tissues using S-P immunohistochemical technique. ResultsDecreased expression of P12 and overexpression of cyclin D1 were revealed in colorectal carcinoma. Decreased expression of P21 was related to lymph node metastasis. No cor- relation was found between cyclin D1 and clinicopathological parameters. Conclusion Decreased expression of P21 and overexpression of cyclin D1 may be involved in colorectal tumorigenesis,and were associated with poor prognosis. No correlation was found between P21 and cyclin D1 in colorectai carcinoma.
