EFFECTS OF BU GU ZHI(PSORALEA CORYLIFOLIA L) AND BAI ZHI (DAHURIAN ANGELICA ROOT) EXTRACTS ON MELANOCYTE ADHESION AND MIGRATION
- Author:
Huiqun MA
;
Jie FENG
;
Xianqi ZHANG
;
Kuanhou MU
;
Chao LIU
;
Xinwu NIU
;
Qianli DANG
- Publication Type:Journal Article
- Keywords:
Bu Gu Zhi(Psoralea corylifolia L);
Bai Zhi(Dahurian angelica root);
Melanocyte;
Adhesion;
Migration;
vitiligo
- From:
Journal of Pharmaceutical Analysis
2005;17(1):72-74,89
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find direct effect of Chinese herbs Bu Gu Zhi (Psoralea corylifolia L) and Bai Zhi (Dahurian angelica root) Extracts on melanocyte adhesion and migration in vitro. Methods Ethanol extracts obtained from two kind of Chinese medicinable herbs were tested. Human melanocytes were obtained from neonatal foreskins and 48-well culture dish covered with fibronectin were used to perform melanocyte adhesion assay; Motility was assessed using the micropore filter method. Results: The extracts of Bu Gu Zhi(Psoralea corylifolia L), Bai Zhi(Dahurian angelica root) obviously showed an effect in increasing of human melanocyte adhesion and migration on fibronectin. Conclusion It is suggested that Buguzhi(Fructus Psoraleae) and Baizhi(Radix Angelicae Dahuricae) might induce melanocyte adhesion and/or migration in the treatment of vitiligo.
