The clinical significance of the change of serum HER2/neu concentration during neoadjuvant chemotherapy of the HER2-overexpressed breast cancer
10.3760/cma.j.issn.1674-6090.2013.05.005
- VernacularTitle:血清HER2/neu在HER2过表达型乳腺癌新辅助化疗中的变化及意义
- Author:
Yufeng YAO
;
Rong MA
;
Jianping GONG
;
Jianwei QIN
;
Jinhai TANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasm;
Serum HER2/neu;
Neoadjuvant chemotherapy
- From:Journal of Endocrine Surgery
2013;7(5):368-370,383
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the change of serum HER2/neu concentration during neoadjuvant chemotherapy for HER2-overexpressed breast cancer and its correlation with the response to the neoadjuvant chemotherapy.Methods The concentration of the serum HER2/neu in 78 cases of HER2-overexpressed advanced breast cancer treated with neoadjuvant chemotherapy were detected with enzyme-linked immunosordent assay(ELISA).The relationship between the serum HER2/neu concentration and the response of neoadjuvant chemotherapy was analyzed.Results The serum HER2/neu concentration of befor and after neoadjuvant chemotherapy was 18.6 ± 10.0ng/ml,11.6 ± 6.lng/ml respectively.The serum HER2/neu concentration decreased significantly(P ＜ 0.001).The response of neoadjuvant chemotherapy was correlated with the change of the serum HER2/neu concentration.The pathologic complete response was correlated with the serum HER2/neu concentration of prechemotherapy and the change of the serum HER2/neu concentration.Conclusion The change of serum HER2/neu concentration may serve as a marker predicting the response of neoadjuvant chemotherapy in HER2-overexpressed breast cancer.
