Radiosensitivity of β-elemene on rabbit VX2 renal transplant carcinoma model
- Author:
Junjun SHE
;
Ziming WANG
;
Pengge ZHANG
;
Weimin GAN
;
Wei CHENG
;
Tie CHONG
;
Xiangming CHE
- Publication Type:Journal Article
- Keywords:
β-elemene;
rabbit VX2 carcinoma model;
radiosensitization;
apoptosis
- From:
Journal of Pharmaceutical Analysis
2007;19(2):217-219,234
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of low dosage of β-elemene on the radiosensitivity of rabbit VX2 renal transplant carcinoma model. Methods We took the rabbit VX2 renal transplant carcinoma as the model. Experimental rabbits were divided into three groups: the control group, the radiation group, and the radiation +β-elemene (radiosensitivity) group. The change of tumor was observed by Spiral CT and B ultrasound to compare its regrowth period. The tumor was measured by light microscopy and electron microscopy. Results The tumor in radiosensitivity group was restrained obviously and the sensitization enhancement ratio (SER) of β-elemene was 1.89. Different apoptosis was observed under transmission electron microscopy. Conclusion Low dosage β-elemene can enhance the radiosensitivity of rabbit VX2 renal transplant carcinoma model and induce the apoptosis of tumor cells, but the mechanism needs further study. It promotes apoptosis in mechanisms in vitro.
