Effect of Enhanced External Counterpulsation and Cardiac Rehabilitation on Quality of Life, Plasma Nitric Oxide, Endothelin 1 and High Sensitive CRP in Patients With Coronary Artery Disease: A Pilot Study.
10.5535/arm.2015.39.2.191
- Author:
Seyed Kazem SHAKOURI
1
;
Zeynab RAZAVI
;
Fariba ESLAMIAN
;
Homayoun SADEGHI-BAZARGANI
;
Samad GHAFFARI
;
Arash BABAEI-GHAZANI
Author Information
1. Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
- Publication Type:Clinical Trial ; Randomized Controlled Trial ; Original Article
- Keywords:
Enhanced external counter pulsation (EECP);
Coronary artery disease;
Nitric oxide;
Endothelins;
High-sensitivity C-reactive protein
- MeSH:
C-Reactive Protein;
Coronary Artery Disease*;
Counterpulsation*;
Endothelin-1*;
Endothelins;
Humans;
Male;
Nitric Oxide*;
Pilot Projects*;
Plasma*;
Quality of Life*;
Rehabilitation*
- From:Annals of Rehabilitation Medicine
2015;39(2):191-198
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To investigate the effect of enhanced external counterpulsation (EECP) on plasma nitric oxide (NO), Endothelin 1 (ET1), high sensitive C-reactive protein (HSCRP) and quality of life (QoL) in patients with coronary artery disease (CAD). METHODS: We conducted a pilot randomized clinical trial in order to evaluate plasma NO, ET1, HSCRP and QoL before and after twenty sessions of EECP (group A) and cardiac rehabilitation (CR, group B) in 42 patients with CAD (21 in each group). RESULTS: Forty-two patients (33 male and 9 female) were included in the study. The mean age was 58.2+/-10 years. The mean HSCRP was 1.52+/-0.7 in the EECP group and it was reduced to 1.27+/-0.4 after intervention. The reduction in HSCRP was not statistically significant in EECP and CR groups with p=0.33 and p=0.27, respectively. There was not significant improvement of NO, ET1, and QoL in the EECP and CR groups shortly after therapy (p>0.05). CONCLUSION: Although the short-term EECP treatment in CAD patients improved HSCRP, NO, ET1, and QoL compared with the baseline those improvements are not statistically significant. Further studies are necessary with large study groups and more sessions.
