Revascularization for Patients with Idiopathic Thrombocytopenic Purpura and Coronary Artery Disease.
10.4070/kcj.2014.44.4.264
- Author:
Chan Hee LEE
1
;
Ung KIM
Author Information
1. Division of Cardiology, Yeungnam University Medical Center, Daegu, Korea. woongwa@hanmail.net
- Publication Type:Case Report
- Keywords:
Idiopathic thrombocytopenic purpura;
Coronary artery disease;
Myocardial revascularization
- MeSH:
Atherosclerosis;
Autoantibodies;
Blood Platelets;
Coronary Artery Disease*;
Hemorrhage;
Humans;
Immunization, Passive;
Myocardial Revascularization;
Platelet Count;
Prevalence;
Purpura, Thrombocytopenic, Idiopathic*;
Thrombosis
- From:Korean Circulation Journal
2014;44(4):264-267
- CountryRepublic of Korea
- Language:English
-
Abstract:
Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder with a low platelet count characterized by premature platelet destruction and suppression of platelet production mediated by autoantibodies, which may predispose to bleeding. Although the prevalence of coronary artery disease (CAD) in ITP seems to be rare, their co-occurrence is not unusual. Patients with ITP have increased risks for thrombosis and atherosclerosis associated with hemostatic factors, endothelial damage, and the negative effects of steroid and immunoglobulin therapies. Thus, the coexistence of ITP and CAD presents complex problems requiring a balance between hemorrhagic risk and prevention of thrombosis. Here, the authors present two patients with ITP, who were revascularized in different ways for CAD. Although the optimal management of thrombocytopenic patients with CAD is uncertain, individualized treatment modalities can be useful in patients with ITP and CAD.
