EFFECT OF ASCORBIC ACID ON ISCHEMIA-REPERFUSIONARRHYTHMIAS IN ISOLATED GUINEA PIG RIGHT VENTRICULARWALL
- Author:
Shuqin LIU
;
Bingxiang YUAN
;
Zengli LI
- Publication Type:Journal Article
- Keywords:
ascorbic acid;
ischemia-reperfusion;
arrhythmia;
electrophysiology
- From:
Journal of Pharmaceutical Analysis
2000;12(1):19-22,封三
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of ascorbic acid on myocardium from ischemia and reperfusion injury and its electrophysiological mechanism. Methods Using modified Ferrier's arrhythmia induced by ischemia and reperfusion injury in isolated guinea pig right ventricular wall. Results Ascorbic acid at 5, 10, 50 and 100μmol/L slightly decrease incidence of ischemia arrhythmia (P ＞ 0. 05). In contrast, ascorbic acid at 10, 50 and 100μmol/L significantly reduced the incidence of arrhythmia during early reperfusion(2～12min) (P ＜ 0. 01 or P ＜ 0. 001). Ascorbic acid at 5～ 100μmol/L didn't reverse the abbrevating of APD of endocardium and epicardium and didn't affect the conduction time in endocardium (P ＞ 0. 05). However, ascorbic acid abbreviated epicardial conduc tion time significantly (P ＜ 0. 05 or P ＜ 0. 01 or P ＜ 0. 001 ). Conclusion The study suggests that ascorbic acid might exert antiarrhythmic effect via alleviating conduction abnormity to avoid transmural reentries during ischemia and early reperfusion.
