HExDB: Human EXon DataBase for Alternative Splicing Pattern Analysis.
- Author:
Junghwan PARK
1
;
Minho LEE
;
Jong BHAK
Author Information
1. Department of BioSystems, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.
- Publication Type:Original Article
- Keywords:
HExDB;
Exon database;
Alternative splicing
- MeSH:
Alternative Splicing*;
Animals;
DNA, Complementary;
Ecthyma, Contagious;
Exons*;
Genome;
Humans*;
Open Reading Frames
- From:Genomics & Informatics
2005;3(3):80-85
- CountryRepublic of Korea
- Language:English
-
Abstract:
HExDB is a database for analyzing exon and splicing pattern information in Homo sapiens. HExDB is useful for specific purposes: 1) to design primers for exon amplification from cDNA and 2) to understand the change of ORFs by alternative splicing. HExDB was constructed by integrating data from AltExtron which is the computationally predicted exon database, Ensemble cDNA annotation, and Affymetrix genome tile published recently. Although it may contain false positive data, HExDB is good starting point due to its sensitivity. At present, there are as many as 2,046,519 exons stored in the HExDB. We found that 16.8% of the exons in the database was constitutive exons and 83.1% were novel gene exons.
