The Role of B-type Natriuretic Peptide in Predicting Postoperative Complications and Outcomes in Patients Undergoing Coronary Artery Bypass Graft.
- Author:
Tae Eun JUNG
1
;
Dong Hyup LEE
;
Jang Hoon LEE
;
Hyung Dong DO
;
Sung Sae HAN
Author Information
1. Department of Thoracic and Cardiovascular Surgery, College of Medicine, Yeungnam University, Korea. dhlee@med.yu.ac.kr
- Publication Type:Original Article
- Keywords:
Complication;
Brain natriuretic factor;
Coronary artery bypass graft
- MeSH:
Coronary Artery Bypass;
Coronary Vessels;
Heart Failure;
Humans;
Intensive Care Units;
Natriuretic Peptide, Brain;
Postoperative Complications;
Prospective Studies;
ROC Curve;
Sensitivity and Specificity;
Transplants
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2008;41(1):55-60
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Circulating levels of brain natriuretic peptide (BNP) provide prognostic information for patients with heart failure. The aim of our study was to investigate whether preoperative and postoperative BNP levels could predict postoperative complications and outcomes in patients after coronary artery bypass graft (CABG). MATERIAL AND METHOD: Data was collected prospectively on 30 patients (M/F=19/11, age 60.0+/-9.6 years) undergoing conventional CABG during a 1-year period beginning on January 1, 2005. Patients underwent off-pump CABG, and combined surgery was excluded. The BNP assay was performed preoperatively, immediate postoperatively at the intensive care unit (ICU), and 1, 3, 5, and 7days postoperatively. RESULT: Preoperative BNP levels significantly correlated with preoperative echocardiographic ejection fraction and an ICU stay of 5 days or more (r=-0.4, p=0.028; r=0.39, p=0.031, respectively). A preoperative BNP cut-off value above 263 pg/mL demonstrated high specificity (90.5%) for predicting postoperative complications using the receiver operating characteristics curves. Preoperative and postoperative (7 days) BNP levels were different depending on the abscence (mean BNP=99+/-23 pg/mL vs. 296+/-74 pg/mL, p<0.05) and presence (mean BNP=212+/-29 pg/mL vs. 408+/-23 pg/mL, p<0.01). CONCLUSION: Preoperative BNP levels > 263 pg/mL predict postoperative complications in patients receivingCABG.
