Effect of Hypolipidemic drug on Diabetic Retinopathy.
- Author:
Man Seong SEO
1
;
Kun Jin YANG
;
Yeoung Geol PARK
Author Information
1. Department of Ophthalmology, Chonnam University, Mdeical School, Kwanju, Korea.
- Publication Type:Original Article
- Keywords:
Cholesterol;
Contrast sensitivity;
Diadetic retinopathy
- MeSH:
Cholesterol;
Contrast Sensitivity;
Diabetes Mellitus;
Diabetes Mellitus, Type 2;
Diabetic Retinopathy*;
Follow-Up Studies;
Humans;
Hypercholesterolemia;
Lovastatin;
Retinaldehyde;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
1996;37(7):1154-1160
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The effect of improving hypercholesterolemia on non-proliferative diabetic retinopathy have been evaluated in 18 patients, 34 eyes, with noninsulindependent diabetes mellitus. The patient group took 20mg of lovastatin daily for one month and after then 40mg of lovastatin daily for two months. The control group, 14 eyes, took placebo for 3 months. After follow-up of 6 months, the serum cholesterol concentration was decreased by 21% (from 301.35 +/- 38.48 to 232.97 +/- 19.73mg/dl). The visual contrast sensitivity funtion was improved significantly on the statistics (p=0.005) as compared with the control group. The corrected visual acuity was improved in 11 eyes(32.4%) and retinal lesion was decreased in 10 eyes (29.4%). But they were statistically insignificant. This result suggests lowering the serum cholesterol may make a positive effect on non-proliferative diabetic retinopathy of noninsulin-dependent diabetes mellitus with hypercholesterolemia by means of improving visual contrast sensitivity function.
