The response evaluation and predictive value of Ki67 expression in neoadjuvant chemotherapy for breast cancer
10.3760/cma.j.issn.1674-6090.2014.02.007
- VernacularTitle:Ki67在乳腺癌新辅助化疗中的疗效评价及预测价值
- Author:
Fuyu GONG
;
Benzhong WANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Ki67;
Neo-adjuvant therapy;
Influencing factors
- From:
Journal of Endocrine Surgery
2014;(2):116-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of Ki 67 in 72 cases of breast cancer and to analyze the correlation of Ki67 expression with clinicopathological factors and efficacy of neo-adjuvant chemotherapy .To as-sess the prediction value of Ki 67 in selecting neo-adjuvant chemotherapy .Methods Ki67 expression in tumor tissues of 72 cases of breast cancer was detected before and after neo-adjuvant chemotherapy .Tumor tissues are a-chieved by core needle biopsy .Results Ki67 overexpression was found in those with axillary lymph node ( ALN) metastasis, in pathological stage III and tumor diameter >2 cm(P＜0.05).Ki67 expression was not significantly associated with age(P>0.05).Objective response(OR)rate of neo-adjuvant chemotherapy was 84.2%(61/72). Patients with Ki67 over-expression were more sensitive than those with lower-expression(P>0.05).Positive ex-pression rate of Ki67 was reduced significantly by neo-adjuvant chemotherapy(P＜0.05).Positive expression rate of Ki67 was reduced significantly in pathological complete response ( PCR ) group, clinical complete remission (CCR)group and partial response(PR)group.Conclusion The expression of Ki67 may be a potential predictive biomarker for neo-adjuvant therapy response in patients of breast cancer and can provide the basis for individual therapy for breast cancer .
