Alteration of coagulogram in women with polycystic ovary syndrome
10.3760/cma.j.issn.1674-6090.2014.02.021
- VernacularTitle:多囊卵巢综合征患者凝血功能改变
- Author:
Hongyu CHEN
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Coagulogram;
Thrombophilia
- From:
Journal of Endocrine Surgery
2014;(2):159-162
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the alteration of coagulogram in patients with polycystic ovary syn -drome(PCOS).Methods Coagulogram was compared between 48 patients with PCOS and 42 healthy women. Pre-and post-therapy coagulogram were also compared and the correlation of coagulogram alternation and endocrine indicators were analyzed in PCOS patients .Results The mean age of the 48 PCOS patients was 27.6 ±4.2. Compared to the healthy women , PCOS patients presented higher body mass index , testosterone , insulin and fast-ing blood glucose levels ( P＜0.05 ) .Refer to the coagulogram , PCOS patients showed shorter prothrombin time and activated partial thromboplastin time , lower international normalized ratio of prothrombin time ratio , and the activity of thrombin(P＜0.05), longer thrombin time and lower fibrinogen , D Dimer and fibrin degradation prod-uct levels(P＜0.05).After three circles of treatment, the above indicators of coagulogram were recovered (P＜0.05).Moreover, the alteration of international normalized ratio was associated with fasting blood glucose and in-sulin significantly(P＜0.05).The alteration of D Dimer and fibrin degradation product were associated with fast-ing blood glucose, insulin and testosterone significantly (P＜0.05).Conclusions PCOS patients showed relative hypercoagulatory and hypofibrinolytic status which may be induced by hyperglycemia , hyperinsulinemia and hyper androgenemia.Thus, coagulogram should be monitored and interfered in PCOS patients to prevent thrombosis .
