Macrofollicular variant of papillary thyroid carcinoma：report of 2 cases and literature review
10.3760/cma.j.issn.1674-6090.2014.04.006
- VernacularTitle:巨滤泡型甲状腺乳头状癌二例报道及文献复习
- Author:
Fang ZHANG
;
Qiong LIAO
- Publication Type:Journal Article
- Keywords:
Thyroid tumors;
Papillary carcinoma;
Macrofollicular variant
- From:
Journal of Endocrine Surgery
2014;(4):282-285
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the pathological morphological features of the macrofollicular variant of papillary thyroid carcinoma ( MFPTC ) .Methods Clinical data of 2 cases of MFPTC were reviewed .The his-topathological and immunohistochemical features were analyzed .Relevant literatures were reviewed .Results The histological characters of MFPTC mainly included its multiple macrofolliculus , plenty of colloid and atypical nuclear morphology.Immunohistochemistry stain showed cytokeratin-19, Galectin-3 and HBME-1 expressed simultaneously. Conclusions MFPTC is a thyroid papillary carcinoma with unique histological characters .It should be differen-tially diagnosed from some benign lesions such as nodular goiter and follicular adenoma .Immunohistochemical stain of cytokeratin-19, Galection-3 and HBME-1 may be very helpful in the diagnosis and differential diagnosis .
