Meta analysis of prognostic factors and surgical extent of papillary thyroid microcarcinoma

VernacularTitle:甲状腺乳头状微小癌预后因素及手术范围的Meta分析
Author: Haifeng ZHANG ; Yang WANG ; Jun LUO ; Yuanzhi ZHU ; Ye TIAN ; Chao BAI ; Xinxi LI
Publication Type:Journal Article
Keywords: Thyroid cancer/Papillary; Survival analysis; Neck dissection; Recurrence; Meta analysis
From: Journal of Endocrine Surgery 2011;05(4):255-259
CountryChina
Language:Chinese
Abstract: ObjectiveTo study prognostic factors and surgical extent of papillary thyroid microcarcinona (PTMC). MethodsLiteratures about PTMC were searched. Relationship between prognostic factors and recurrence after initial operation was analyzed by meta analysis. The surgical extent of PTMC was discussed. Results A total of 12 retrospective studies were included. Meta analysis results showed that factors such as male, tumor size ＞ 5 mm, nonincidental, positive lymphnode, multifocus, and capsular invasion were related to recurrence after initial surgery. Age above 45 years had nothing to do with the recurrence rate of PTMC. There was no signifi.cant difference in recurrence rate between prophylactic neck dissection groups and the groups without prophylactic neck dissection. ConclusionsMany factors are related to the prognosis of PTMC. The surgical extent depends on prognostic factors. Prophylactic neck dissection is not supposed to be conventional surgical procedure for PTMC. Bilateral central lymph node dissection is appropriate to PTMC with positive lymph node.