Correlation of the expression of survivin and caspase-3 proteins in juvenile laryngeal papilloma

VernacularTitle:儿童喉乳头状瘤组织中Survivin及Caspase-3蛋白表达及相关性研究
Author: Wu WANG ; Yuanda ZHOU ; Haixia HE
Publication Type:Journal Article
Keywords: juvenile laryngeal papilloma; surviving; caspase-3; apoptosis
From: Journal of Cellular and Molecular Immunology 2009;25(11):1034-1035
CountryChina
Language:Chinese
Abstract: AIM: To investigate correlation between the expression of survivin and caspase-3 proteins in juvenile laryngeal papilloma. METHODS: The expression of survivin and caspase-3 proteins were detected with immunohistochemial method in 43 cases of juvenile laryngeal papilloma, 25 vocal nodules and 25 normal laryngeal mucosa. RESULTS: The positive rates of survivin protein in juvenile laryngeal papilloma were 57.14% and higher than that in voeal nodules (P<0.01)and the normal laryngeal moeusa (P<0.01). And the Caspase-3 protein positive rate was 26.19% in juvenile laryngeal papilloma and lower than that in voeal nodules and the normal laryngeal mucosa (P<0.01).There was a significant negative correlation between the expression of survivin and caspase-3 in juvenile laryngeal papilloma. CONCLUSION: The abnormal expression of survivin and caspase-3 may play important role in the pathogenesis of juvenile laryngeal papilloma.