Research on relationship between expressions of apoptosis-related gene bcl-x and bax in hepatocellular carcinoma and its clinical pathological features
10.3321/j.issn:1007-8738.2001.04.019
- VernacularTitle:bcl-x、 bax基因表达与肝细胞癌临床病理特征的关系
- Author:
Hongyong XU
;
Kaizong LI
;
Youchi FU
;
Kefeng DOU
;
Jingmeng LI
- Publication Type:Journal Article
- From:
Journal of Cellular and Molecular Immunology
2001;17(4):356-358
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study relationship between expressions of apoptosis-related gene bax and bcl-x in heopatocellular carcinoma (HCC) tissues and its clinical feature. Mothods The expression of Bax and Bcl-x were determined by immunohistochemistry with EnvisionTM system. Results Bcl-x and Bax proteins were detectable in 20 and 19 out of 40 HCCs, respectively. Their expressions in HCC cells were lower than those in cirrhosis(P＜ 0.05), The expression of Bax and Bcl-x in highly or intermediatly differentiated HCC cells were highed than that in low-diffe-rehtiated HCC cells suggesting that there was significant relationship among bcl-x and bax expressions and differential degree， clinical stages of HCC cells， and AFP level. However, the expression of this proteins showed no relationship with patient's sex and age(＞ 60 or ＜ 60 years old) (＞ 0.05). Conclusion Apoptosis-related genes bcl-x and bax participate partially in apoptotic regulation of HCC cells, and show that their expressions have correlation with differential degree, clinical stage of HCC cells and AFP levels.
