Detection and its clinical significance of anti-idiotypic antibodies directed against rabbit anti-keratin autoantibodies
10.3321/j.issn:1007-8738.2001.04.025
- VernacularTitle:家兔抗角蛋白自身抗体独特型抗体的产生及临床意义
- Author:
Rushan XIA
;
Yufeng LIU
;
Wei LI
;
Chengxin LI
;
Yehong WAN
;
Yuping DANG
- Publication Type:Journal Article
- From:
Journal of Cellular and Molecular Immunology
2001;17(4):371-373
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the production of anti-idiotypic antibodies directed against AK auto Ab in the rabbit sera after long-term, high dose allogenic AK auto Ab injection. Methods Allogenic AK auto Ab (5mg/kg)was injected intramuscularly to rabbit once every other day for 90 days. Anti-idiotypic antibodies in rabbit sera were detected by ELISA. Results Rabbits injected with AK auto Ab generated anti-idiotypic antibodies that could react to F(ab′ )2 of AK auto Ab. The titers of anti-idiotypic antibodies reached the highest levels at 4 weeks after the administration of AK auto Ab and then gradually decreased. Conclusion Rabbits could be induced to form immune tolerance when high-does allogenic AK auto Ab is administrated for long-term.
