Expression of ER,CyclinD1 in glandular tissue of pubertal mammary hypertrophy

VernacularTitle:ER、CyelinD1蛋白在青春期乳房肥大症乳腺组织中的表达
Author: Min REN ; Ying WANG ; Li TENG ; Benzhong WANG
Publication Type:Journal Article
Keywords: Puberty; Mammary hypertrophy; ER; CyclinD1
From: Journal of Endocrine Surgery 2009;3(5):304-307
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of the ER,CyclinD1 in breast tissue of pubertal mammary hypertrophy and explore the possible etiology of pubertal mammary hypertrophy.Methods The expression of ER,CyclinD1 was detected by Western-blot in 15 cases of pubertal mammary hypertrophy,15 normal breast tissue and 10 cases of micromastia.Results There was significant difference of the expression of ER,CyclinD1 within breast tissue between pubertal mammary hypertrophy and micromastia(P＜0.01).There was significant difference of the expression of ER,CyclinD1 within breast tissue in pubertal mammary hypertrophy and in normal breast tissue(P＜0.01).There was no difference between the expression of ER,CyclinD1 within breast tissue in micromastia and in normal breast tissue(P＞0.05).Conclusions The expression of ER,CyclinD1 in pubertal mammary hypertrophy are significantly higher than in micromastia and normal breast tissue.The pubertal mammary hypertrophy may be related to the expression status of ER,CyclinD1 within breast tissue.