Influence of oxygen-free radical to erythrocyte immune adherent function after severe burns
10.3321/j.issn:1007-8738.2001.04.032
- VernacularTitle:氧自由基对严重烧伤后红细胞免疫粘附功能的影响
- Author:
Xiaodong CHEN
;
Boyu WU
;
Fengyuan HUANG
;
Qiong JIANG
- Publication Type:Journal Article
- From:
Journal of Cellular and Molecular Immunology
2001;17(4):389-391
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the influence of oxygen-free radical to erythrocyte immune adherent function after severe burns. Methods The erythrocyte's immune adherent function (RC3bRR and RICR) and the levels of SOD, Lpo-MDA, CAT, GSH-px and GSH were detected on 1, 3, 5, 7, 14, 21, 28 and 35 days after severe burns, and then their correlations were analyzed. Results The rosette forming rate of erythrocyte C3b receptor (RC3bRR) in post-burn group was obviously lower than that in normal control group (P＜ 0.05～ 0.001), and erythrocyte immune complex rosette forming rate (RICR) of the burned patients was obviously higher than that of the healthy group(P＜ 0.001), but they gradually returned to normal four weeks after burn. Compared with healthy control group, the levels of SOD, CAT, GSH-px and GSH markedly declined(P＜ 0.05～ 0.001), while Lpo-MDA level notably increased(P＜ 0.05～ 0.001), but their recovery needed at least three weeks. RC3bRR was positively correlated with the levels of SOD, CAT, GSH-px and GSH, and was negatively correlated with Lpo-MDA. Correlation of RICR was contrary to that of RC3bRR. Conclusion The degree of the free radical injury may directly influence the erythrocyte membrane function, especially the erythrocyte immune adherent. It is necessary to reducing the production of free radicals and enhacing patient's erythrocyte immune function during burn treatment.
