The effect factors of first iodine-131 ablation of thyroid remnants in patients with differentiated thyroid cancer
10.3760/cma.j.issn.1674-6090.2009.03.008
- VernacularTitle:131I首次清除分化型甲状腺癌残留组织的影响因素探讨
- Author:
Xingguo JING
;
Gang CHENG
- Publication Type:Journal Article
- Keywords:
Differentiated thyroid cancer (DTC);
Iodine-131 ablation
- From:
Journal of Endocrine Surgery
2009;3(3):167-169
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of the first iodine-131 ablation of thyroid remnants in pa-tients with differentiated thyroid cancer (DTC) and discuss factors that may be influential in the treatment. Meth-ods All DTC patients confirmed by pathology received iodine-131 therapy after necessary preparation. Accord-ing different operation procedures, time interval between operation and iodine-131 treatment and dose of iodine - 131, the patients were divided into different groups. Therapy effects were observed in different groups. Results Ablation successful rate was 88.5% in total thyroidectomy group, compared with 44.4% in subtotal thyroidecto-my group. 92.7% ablation rate was seen in the group of I-2 months time interval between operation and iodine - 131 treatment, while in the group of over 1 year time interval, only 50% ablationrate was achieved. Ablation successful rate was 47.6% in the group of low dose of iodine-131 (2.96GBq), compared with 82.8% in the high dose group (4.44GBq). Conclusions Total thyroidectomy and cervical lymph nodes dissection should be recommended for the patients with DTC. The better interval time between operation and iodine-131 ablation thy-roid remnants is 1～2 months. The high dose of iodine-131 shows better result than low dose of iodine-131 treatment.
