Pathological characteristics and prognosis of triple-negative breast cancer

VernacularTitle:三阴性乳腺癌临床病理特征及预后分析
Author: Jianli XU ; Chengyi WU
Publication Type:Journal Article
Keywords: Breast neoplasms; Triple-negative; Clinicopathological characteristics; Prognosis
From: Journal of Endocrine Surgery 2009;3(5):308-312
CountryChina
Language:Chinese
Abstract: Objective To explore the pathological characteristics and prognosis of triple-negative breast cancer(TNBC).Methods The pathological data of 465 cases of operable primary breast cancer were analyzed.TNBC was immunohistochemically defined by a lack of expression of ER,PR and Her-2.The differences of pathological characteristics and prognosis between TNBC and non-TNBC were explored.Results TNBC count for about 15%(73/465)of all breast carcinomas.TNBC correlated with younger(＜50y)and premenopausal women (P＜0.05).The follow-up time of the 369 cases was truncated at January 2009,and 39 cases had recurrence or metastasis,the relapse rate of TNBC(18.3%,11/60)was higher than that of non-TNBC(9.1%,28/309,P=0.033).Conclusions The patients with TNBC were younger,and had an increased likelihood of relapse.