The effect of radiofrequency on sodium/iodide symporter expression in thyroid cancer cell

VernacularTitle:射频对甲状腺癌细胞钠/碘转运体表达的影响
Author: Qinjiang LIU ; Feng DONG ; Shihong MA
Publication Type:Journal Article
Keywords: Thyroid carcinoma; Radiofrequency ablation; Sodium/iodide symporter
From: Journal of Endocrine Surgery 2010;04(6):383-387
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of radiofrequency on sodium/iodide symporter expression in thyroid cancer cell. Methods 29 thyroid cancer patients with low or no expression of sodium/iodide symporter underwent radiofrequency ablation combining 131I radiotherapy. Whole-body nuclide imaging and serum Ig were examined before and after radiofrequency ablation. Results Whole-body nuclide imaging showed that there were 4 cases (4/29) positive before radiofrequency ablation, 19 cases (19/29) positive two weeks after radiofrequency ablation and 12 cases (12/29) positive four weeks after radiofrequency ablation. Four weeks after radiofrequency ablation, 4 cases showed an increased serum Ig level, 17 cases with a decreased serum Ig level and 17 cases without any change in serum Ig level. The total effective cases were 25 (25/29) and 15 cases (15/29) were completely cured. Conclusion Radiofrequency ablation induces thyroid cancer cells without sodium/iodide symporter expression to resume iodine intake and thus increased clinical effect of 131I on undifferentiated thyroid cancer.