Surgical management of the secondary hyperparathyroidism

VernacularTitle:继发性甲状旁腺功能亢进的外科治疗
Author: Jiangwen LIU ; Junqiang XIA ; Qi WANG ; Changhui DENG ; Jiaming LIU ; Li YAO
Publication Type:Journal Article
Keywords: Parathyroidectomy; Chronic renal failure; Hyperparathyroidism
From: Journal of Endocrine Surgery 2009;3(6):402-405
CountryChina
Language:Chinese
Abstract: Objective To study the clinical effect of total parathyroidectomy on the patient with secondary hyperparathyroidism related to chronic renal failure. Methods The clinical data of 12 cases of total parathyroidectomy were retrospectively analyzed. All changes between preoperation and postoperation were compared, that included the clinical presentations, serum calcium and phosphate, plasma alkaline phosphatase (AKP), parathyroid hormone (iPTH), blood haematocrit (HCT), blood-lipid(TG) and complications. Results The clinical symptoms and signs were markedly improved in all cases. A postoperative decrease in the laboratory indexes of serum calcium and phosphate, AKP, iPTH, HCT was also observed(P<0.05). But the difference of TG did not reach statistical significance(P>0.05). Hypocalcaemia occurred in all patierts in different degrees. Plasma iPTH maintained at high level in 1 case and recurrence happened in 1 case after operation. Conclusions Total parathyroidectomy is an effective treatment for severe uremic secondary hyperparathyroidism and can improve the patient's life quality.