Expression and clinical significance of RhoC protein in breast cancer
10.3760/cma.j.issn.1674-6090.2011.03.011
- VernacularTitle:RhoC蛋白在乳腺癌中的表达及临床意义
- Author:
Li FANG
;
Xiongbin HE
- Publication Type:Journal Article
- Keywords:
Breast cancer;
RhoC protein;
MVD
- From:
Journal of Endocrine Surgery
2011;05(3):176-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of RhoC protein in breast cancer.Methods Expression of RhoC protein was detected by immunohistochemlstry in 112 cases of breast cancer,20 cases of adjscent non-cancerous normal tissues and 15 cases of normal mammary gland tissues.The relation between expression of RhoC protein and clinicopathological characteristics was analyzed.Expression of CD34 in breast cancer tissues was detected.Microvessel density(MVD)was calculated and its correlation with RhoC protein Was analyzed.Results RhoC had a positive expression rate of 40.2%(45/112)in breast cancer,while it was not expressed in adjacent non-cancerous tissues or normal mammary gland tissues.Rhoc expression in breast tissues was related to lymph node metastasis and pathological stages(P<0.05).MVD value in patients with positive RhoC expression was significantly higher than that in patients with negative RhoC expression(P<0.05).Conclusions The expression of RhoC protein is related to lymphatic metastasis,pathological stages and MVD value.The upregulation of RhoC protein expression may promote the metastasis and invasion of breast cancer.