Relevance between GGF, NGF and growth characteristics of PRL
10.3760/cma.j.issn.1674-6090.2011.04.005
- VernacularTitle:胶质细胞生长因子、神经生长因子与泌乳素垂体瘤生长特性的相关性研究
- Author:
Yuhai ZHANG
;
Yunxue YANG
;
Wei DING
;
Guoqing SUN
;
Jun DONG
;
Wengong BAO
- Publication Type:Journal Article
- Keywords:
Glial growth factor;
Nerve growth factor;
PRL;
Microvessel density;
Cell proliferation
- From:
Journal of Endocrine Surgery
2011;05(4):230-234
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the relationship between glial growth factor (GGF), nerve growth factor (NGF) and growth characteristics of prolactinoma (PRL) and to evaluate pre and postoperative growth of PRL. MethodsImmunohistochemistry was used to analyze expression of GGF and NGF in 86 cases of PRL and to analyze the relationship between expression of GGF, NGF and PRL level, invasion, stroke, microvessel density. Cells were cultured with GGF and NGF to observe cell growth, cell cycle and angiogenesis. The relationship between proliferation, growth rate and GGF, NGF was evaluated by rank correlation and Chi-square test. Results GGF expression was significantly higher in invasive, stroke and recurrent pituitary adenomas ( P ＜ 0.05 ).Microvessel density increased significantly ( P ＜ 0.01 ). NGF expression was significantly lower in invasive, apoplexy and recurrent adenomas ( P ＜ 0. 05 ). Microvessel density decreased dramatically with NGF interruption ( P ＜ 0.05 ). GGF showed a positive correlation with growth rate of PRL. NGF showed a negative correlation with invasion and stroke. ConclusionsGGF is one of the factors facilitating growth and invasion of PRL while NGF can partly restrain proliferation of PRL cells. Expression of GGF and NGF indirectly reflects proliferation activity of PRL and can be used as markers to evaluate invasion, recurrence, treatment response and prognosis of PRL.
