The effect of gastric bypass on type 2 diabetes mellitus patients with different preoperative glycosylated hemoglobin level

VernacularTitle:术前糖化血红蛋白水平对T2DM患者胃旁路术降糖效果的影响
Author: Kerong LIN ; Bin LIU ; Yu WANG ; Chang WANG ; Yibo WANG ; Yabin JIAO ; Lujie DAI ; Ruijiao LIN ; Sheng HUANG
Publication Type:Journal Article
Keywords: Gastric bypass; Type 2 diabetes mellitus; Glycosylated hemoglobin; Blood glucose
From: Journal of Endocrine Surgery 2011;05(5):320-322
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effect of Roux-en-Y gastric bypass on patients with different preoperative glycosylated hemoglobin (HbAlc) level.Methods From Jan.2008 to Dec.2009,54 patients with gastric lesions and type 2 diabetes mellitus were preoperatively divided into 3 groups:group A (HbAlc:6.5％ -7.9％ ),group B ( HbAlc:8.0％ - 9.9％ ),and group C ( HbAlc ＞ 10％ ).They all underwent Roux-en-Y gastric bypass.The fasting plasma glucose(FPG) and HbAlc concentration were measured before surgery and 12,24,48 weeks after surgery.The antidiabetic medication was analyzed before surgery and 48 weeks after surgery.Results FPG and HbAlc concentration decreased significantly after surgery ( P ＜ 0.01 ).FPG and HbAlc concentration differed greatly between the different groups ( P ＜ 0.01 ).With the increase of preoperative HbAlc,FPG and HbAlc concentrations were poorly controlled after surgery.Conclusion Roux-en-Y gastric bypass surgery can effectively improve glucose metabolism for patients with preoperative HbAlc ＜ 10％.