Comparison of male and female resectable breast cancer and their clinicopathological characteristics
10.3760/cma.j.issn.1674-6090.2012.02.009
- VernacularTitle:可手术男性和女性乳腺癌的配对比较及临床特点
- Author:
Yunwei HAN
;
Xinzhong CHANG
;
Shaoyan WEN
;
Xin WANG
- Publication Type:Journal Article
- Keywords:
Male breast cancer;
Clinicopathologic features;
Prognosis;
Matching analysis
- From:
Journal of Endocrine Surgery
2012;06(2):102-105
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze clinicopathological characteristics and treatment of male breast cancer (MBC) and the matched female breast cancer (FBC). To compare the survival difference between the 2 groups.To study the factors influencing the prognosis of MBC.Methods63 MBC patients treated in Tianjin Medical University Cancer Institute and Hospital from Jan.1995 to Dec.2008 were enrolled in this study.Each MBC patient in the database was matched with 2 FBC patients.The matching criteria were with similar age, diagnosis time, and TNM stage.Chi-square test and Fisher exact test were employed to compare the clinicopathologic characteristics of MBC and FBC.Kaplan-Meier method, Log-rank test, and Cox hazard regression model were employed respectively to make survival analysis, surival rate comparison and multivariate analysis.ResultsThe 10-year disease-free survival (DFS) rate was 53.9％ for men and 65.1％ for women (P =0.047).The 10-year overall survival (OS) rate was 61.9％ for men and 77％ for women (P =0.032).Univariate analysis showed TNM stage, surgical method and recurrence were factors influencing the prognosis of MBC patients. Multivariate analysis showed TNM stage was an independent factor influencing the prognosis of MBC patients.ConclusionsFBC patients had a better 10-year OS rate and DFS rate than MBC patients.TNM stage is an independent factor influencing the prognosis of MBC patients.
