Research of the relationship between vascular endothelial growth factor-C and lymph node metastasis of breast cancer

VernacularTitle:血管内皮生长因子-C与乳腺癌淋巴结转移关系的研究
Author: Lixiang WANG ; Feng GAO
Publication Type:Journal Article
Keywords: Breast cancer; Lymph node metastasis; VEGF-C
From: Journal of Endocrine Surgery 2009;3(6):374-377
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of VEGF-C in breast cancer and its relationship with lymph node metastasis. Methods VEGF-C expression was assessed by immunohistochemistry in 78 cases of breast cancer. The relationship between expression of VEGF-C and lymph node status and clinicopathological features in breast cancer was analyzed. 20 cases of breast fibroadenoma was taken as control group. Results The expression of VEGF-C was significantly higher in breast cancer group than that in fibroadenoma group(P<0.01). VEGF-C was significantly higher in axillary lymph node-positive group than that in axillary lymph node-negative group(P<0.05). No relativity was found between VEGF-C and patient age, tumor size, estrogen receptor status, progesterone receptor status, and clinical stage. Conclusion The high expression of VEGF-C has a relativity with lymph node metastasis of breast cancer and may be important for the breast cancer's prognosis.