PCNA and hMSH2 in breast cancer tissues
10.3760/cma.j.issn.1674-6090.2012.02.003
- VernacularTitle:PCNA和hMSH2在乳腺癌组织中的表达及意义
- Author:
Jie QI
;
Jianhua CHEN
;
Yundi GUO
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Proliferating cell nuclear antigen;
Human MutS honolog2 gene
- From:
Journal of Endocrine Surgery
2012;06(2):81-83
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the relationship between the expression of human proliferating cell nuclear antigen (PCNA) and human MutS honolog2 gene (hMSH2) in breast cancer and its significance. Methods PCNA and hMSH2 expression were detected in 68 cases of breast cancer tissues by immunohistochemistry.ResultsAmong the 68 cases of breast cancer, the expression rate of PCNA and hMSH2 was 44.1％ (30/68) and 54.4％ (37/68) respectively.The expression of PCNA and hMSH2 was positively correlated with lymph nodes metastasis(P ＜0.05).PCNA expression was positively correlated to hMSH2 expression in breast cancer (P ＜0.05).ConclusionInteraction between PCNA and hMSH2 may be related to the carcinogenesis of breast cancer.Effective detection of PCNA and hMSH2 proteins may contribute to the evaluation of malignancy and biological behavior of breast cancer.
