Meta-Analysis on the safety of total thyroidectomy combined with central lymph node dissection

VernacularTitle:甲状腺全切联合中央区淋巴结清扫术安全性的Meta分析
Author: Ye PAN ; Qi ZHENG ; Youben FAN ; Bo WU ; Xiaodong HAN
Publication Type:Journal Article
Keywords: Thyroid carcinoma; Central lymph node dissection; Hypocalcemia; Vocal cord palsy; Meta-analysis
From: Journal of Endocrine Surgery 2010;04(6):379-382
CountryChina
Language:Chinese
Abstract: Objective To evaluate the safety of performing thyroidectomy together with central lymph node dissection(CLND). Methods Meta analysis was performed on 7 selected clinical papers using MantelHaenszel method and relative risk was calculated. Results A total of 1524 patients were eligible to be included,among whom 904 cases underwent thyroidectomy alone and 620 cases underwent total thyroidectomy combined with CLND. The risk rate of temporary hypocalcemia and temporary vocal cord palsy for CLND was 24. 77% and 9. 12% respectively, which was higher than that in performing thyroidectomy alone. However, the risk of permanent hypocalcemia and permanent vocal cord palsy had no statistic difference between the two groups. Conclusion As there is no increased morbidity of CLND, it is prudently suggested to give a prophylactic CLND for patients with high risk of thyroid papillary carcinoma.