Expression of Annexin Ⅱ and uPA in thyroid cancer and their clinical significances
10.3760/cma.j.issn.1674-6090.2012.04.001
- VernacularTitle:AnnexinⅡ、尿激酶型纤溶酶原激活剂在甲状腺癌中的表达及临床意义
- Author:
Xia LI
;
Fang SHI
;
Xinguang QIU
;
Daoming LI
- Publication Type:Journal Article
- Keywords:
Papillary thyroid cancer;
Annexin Ⅱ;
uPA;
Immunohistochemistry;
Metastasis
- From:
Journal of Endocrine Surgery
2012;06(4):217-220
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of Annexin Ⅱ and urokinase-type plasminogen activator(uPA) proteins in the development and lymph node metastasis of thyroid cancer.Methods Immunohistochemistry was used to detect the expression of Annexin Ⅱ and uPA proteins in 35 cases of papillary thyroid cancer tissues,10 cases of thyroid adenoma tissues,16 cases of nodular goiter tissues and 7 cases of normal thyroid tissues.Results The positive expression rate of Annexin Ⅱ and uPA protein was significantly higher in papillary thyroid cancer than in normal thyroid tissues,nodular goiter tissues and thyroid adenoma tissues( P ＜0.05 ).The expression of Annexin Ⅱ and uPA protein was positively correlated in papillary thyroid cancer tissues(P ＜0.05).The expression of Annexin Ⅱ protein in thyroid cancer tissues was associated with tumor size and lymph node metastasis while the expression of uPA protein was only related to lymph node metastasis.Conclusions Annexin Ⅱ and uPA proteins are involved in the occurrence and development of papillary thyroid cancer.They also play a facilitating role in lymph node metastasis of papillary thyroid cancer.
