The relationship between Fas expression and thymocytes spontaneous apoptosis in vitro
10.3321/j.issn:1007-8738.2001.01.011
- VernacularTitle:Fas与体外胸腺细胞自发凋亡的关系
- Author:
Dingwen JIANG
;
Mingqiu GUO
;
Liyin CHEN
;
Xianrong SHEN
;
Li DING
- Publication Type:Journal Article
- From:
Journal of Cellular and Molecular Immunology
2001;17(1):38-40
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the relationship between the expressions of Fas,Fas-L and the spontaneous apoptosis of thymocytes in vitro. Methods The expressions of Fas,Fas-L and the apoptotic rate of thymocytes were assayed by flow cytometry. Results The apoptosis and the Fas expression of thymocytes of different culture times in vitro were increased time-dependently in vitro. The Fas-L expression of thymocytes cultured for 24 h was also significant increase. There was significant corelation between the increase of Fas expression and the increase of apoptosis of thymocytes in vitro. Conclusion Fas is an important molecule which mediates spontaneous apoptosis of thymocytes cultured in vitro.
