Experience of diagnosis and treatment of functional insulinoma:a report of 12 cases
10.3760/cma.j.issn.1674-6090.2010.03.007
- VernacularTitle:功能性胰岛素瘤的诊治(附12例)
- Author:
Xuewen ZHANG
;
Yongsheng YANG
;
Lu ZHANG
;
Yingjun JIE
;
Dan ZHANG
;
Zihui MENG
- Publication Type:Journal Article
- Keywords:
Functional insulinoma
- From:
Journal of Endocrine Surgery
2010;04(3):167-169
- CountryChina
- Language:Chinese
-
Abstract:
Objective To improve the knowledge of the diagnosis and treatment of functional insulinoma. Methods The clinical data of 12 cases of functional insulinoma in China-Japan Union Hospital of Jilin University from 2000 to 2009 were analyzed retrospectively. Results For the 12 cases of functional insulinoma, preoperative fasting blood glucose and the positive rate of insulin were 92% and 89% respectively. The positive rate of IRI/G and C-Peptide reached 100%. The accuracy of the niveau diagnosis of preoperative abdomen ultrasound, CT and of MRI were 75%, 36% and 0% respectively; whereas the accuracy of localization of intraoperative palpation combined with ultrasonography reached 100%. The result of glucose increased by one time within one hour after excision and the rest excision. In the 7 follow-up cases, the symptom of hypoglycemia was not found. There were 3 cases of pancreatic fistula after operation. Conclusions For the suspected cases of functional insulinoma, the measurement of IRI/G and C-Peptide are needed besides measuring blood glucose and insulin. Intraoperative palpation and ultrasonography are effective methods of the localization of functional insulinoma. The complete resection of the insulinoma can be assessed by monitoring the change of the blood glucose after excision as well as the rapid intraoperative pathological examination.
