Change of mGluR1α and mGluR5 in CA1 region of rat brain after infrasonic damage and the protective effect of MCPG
10.3321/j.issn:1007-8738.2001.04.007
- VernacularTitle:次声作用后 mGluR1α、 mGluR5在 CA1区表达的改变及 MCPG的保护作用
- Author:
Zhigang LI
;
Zhou FEI
;
Jingwen WU
;
Keyong JIA
;
Jingzao CHEN
;
Xiaosheng HE
;
Enyu LIU
;
Xianzhen LIU
- Publication Type:Journal Article
- From:
Journal of Cellular and Molecular Immunology
2001;17(4):318-320
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the change of mGluR1α and mGluR5 expression in brain CA1 region after infrasonic action, and the role of antagonist MCPG in rats. Methods 160 SD rats were divided randomly into infrasonic damage group and MCPG therapy group. The two groups were subdivided into control group and 1-time, 7-time and 14-time groups respectively. Rats were exposed to 8Hz, 130dB infrasound two hours each time. Expression of mGluR1α and mGluR5 were detected by immunohistochemical staining and in situ hybridization methods. The morphological changes of neurons after MCPG therapy were observed under microscopes. Results Comparing with the control group, the number and the A value of mGluR1α and mGluR5 positive cells changed after one infrasonic action(P∨ 0.05); and the expression of mGluR1α and mGluR5 in the 7-time group were most obvious(P∨ 0.01); in the 14-time group, they recovered already to normal level. Morphological study confirmed that MCPG protected neurons from infrasonic damage. Conclusion Change of mGluR1α and mGluR5 activity can mediate exciting neurotoxicity after infrasonic action, and it is one of the major factors relative to neurons injury, MCPG had an protective effect on brain damage caused by infrasound.
