Clinical analysis of the effects of dexamethasone on ovulation induction in polycystic ovary syndrome
10.3760/cma.j.issn.1674-6090.2009.02.007
- VernacularTitle:地塞米松对多囊卵巢综合征促排卵治疗效果的影响
- Author:
Fang AI
;
Yan QIU
- Publication Type:Journal Article
- Keywords:
Dexamethasone;
Polycystic Ovary Syndrome (PCOS);
Ovulation induction
- From:
Journal of Endocrine Surgery
2009;3(2):91-94
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of dexamethasone on ovulation induction in polycystic ovary syndrome (PCOS).Methods This clinical study included 68 women with PCOS, which of them were divided into two groups: 34 in dexamethasone treating(dexamethasone combined with ovulation induction) and 34 in con-trol(ovulation induction treatment only).Subsequently, comparisons were made between pre and after drug treat-ment in two groups, the main indexes were the levels of testosterone(T), luteinizing hormone(LH), follicle stim-ulating hormone(FSH), growth rate of follicle, and body mass index(BMI).And we have also considered the o-vulation rate and pregnancy rate, and compared these indexes in dexamethasone treating group with control group.Results There were significant differences between pre and after dexamethasone treatment in the levels of T in treatment group(P < 0.01), and there were not significant differences between pre and after treatment in the lev-els of T in control group (P >0.05).LH had decreased significantly after treatment in both two groups (P <0.01), FSH had not significant differences between pre and after treatment in two groups(P >0.05).The growthrate of follicle of two groups had elevated after treatment (P < 0.01).And the ovulation rate in dexamethasone treating group was higher than that in control group(P < 0.05), but there were not significant differences between the two groups in the clinical pregnancy rates(P >0.05).There were not significant differences between pre and after treatment in the levels of BMI in both two groups (P > 0.05).Conclusions Dexamethasone can decrease the T in plasm levels.It is good for ovulation induction in PCOS.
