Significance of β-catenin and Cyclin D1 express in glioma
10.3321/j.issn:1007-8738.2009.11.014
- VernacularTitle:脑胶质瘤中β-catenin和细胞周期素D1表达的意义
- Author:
Zhiqiang ZHANG
;
Hongqing CHEN
;
Yinghong CHEN
;
Xinfu CHENG
- Publication Type:Journal Article
- Keywords:
gliomas;
β-catenin;
Cyclin D1;
immunohistochemistry
- From:
Journal of Cellular and Molecular Immunology
2009;25(11):1010-1012
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression and the significance of β-catenin and Cyclin D1 in gliomas. METHODS: The SABC immunohistochemistry were used to detect the expression of β-catenin and Cyclin D1 in 49 brain gliomas and 5 normal brain tissues. RESULTS: The β-catenin positive ratio in normal brain tissues and glioma samples are 2/5 and 38/49(P<0.01) respectively, and the Cyclin D1 positive ratio in normal brain tissues and gliomas are 1/5 and 42/49(P<0.01); Compared with the normal brain tissue, both the immunohistochemical expression of β-catenin and Cyclin D1 were up-regulated(P<0.05), and the expression of β-catenin and Cyclin D1 between the normal brain tissues and gliomas exhibited significantly difference (P<0.01). CONCLUSION: β-catenin and Cyclin D1 increased in gliomas may be precipitate the tumorigenesis of glioma.
