Relationship between leptin level and insulin resistance in patients with hypertensive cerebral hemorrhage

VernacularTitle:高血压脑出血患者血清瘦素水平与胰岛素抵抗的关系
Author: Qingju ZHAO ; Xueyuan LI ; Xueguang ZHANG
Publication Type:Journal Article
Keywords: Hypertension; Cerebral hemorrhage; Leptin; Insulin resistance
From: Journal of Endocrine Surgery 2010;04(4):233-235
CountryChina
Language:Chinese
Abstract: Objective To investigate the changes of leptin level in patients with intracerebral hemorrhage and the relationship between leptin level and insulin resistance(IR). Methods 57 patients with hypertensive cerebral hemorrhage (group A ), 50 patients with hypertension (group B), 41 healthy people (group C) were selected to determine the value of fasting blood-glucose ( FBG), fasting blood-insulin( FBI), leptin levels as well as insulin sensitivity index (ISI). Results The level of FNS and leptin was significantly higher (P ＜ 0.05 ) while the level of ISI was lower (P ＜ 0.05 ) in group A than those in group B and C. Correlation analysis showed that leptin level in HCH patients was negatively correlated with ISI, and positively correlated with FNS. Conclusion The results indicate that higher level of leptin and IR may play an important role in the occurrence of hypertension complicated cerebral hemorrhage.