Expression and significance of CD44V6 in thyroid neoplasms

VernacularTitle:甲状腺肿瘤CD44V6的表达及其意义
Author: Wenyou CHEN ; Aiguo YANG ; Song ZHOU ; Kai NIE ; Zhiyong CHEN
Publication Type:Journal Article
Keywords: Thyoid tumor; CD44V6; Immunohistochemistry
From: Journal of Endocrine Surgery 2009;3(1):13-15
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of CD44V6 in thyroid neoplasms and its significance. Methods The expression of CD44V6 in paraffin-embeded thyoid carcinoma tissue from 100 patients (50 with lymph node metastasis,50 without) and 20 patients with thyroid adenoma was measured by immunohistochemistry staining. Results Positive expression of CD44V6 in the group of thyoid carcinoma was 72%, significantly higher than the group of thyroid adenoma.Positive expression of CD44V6 in the group of thyoid carcinoma with lymph node involvement was 90%,significantly higher than the group of thyoid carcinoma without lymph node involvement.In patients with different pathological grade,different clinical stage and different survival time, the positive expression of CD44V6 was significantly different. Conclusions The results suggest that CD44V6 can be regarded as an valuable molecular markers to distinguish benign thyroid tumor from malignant tumor, to predict lymph node metastasis and prognosis.