Significance of S100A4 expression in benign and malignant thyroid tissue

VernacularTitle:S100A4蛋白在甲状腺良恶性病变组织中的表达及其意义
Author: Peizhong SHANG ; Runling NAN ; Huaping GU
Publication Type:Journal Article
Keywords: S100A4 protein; Thyroid disease; Thyroid neoplasm; Metastasis
From: Journal of Endocrine Surgery 2010;04(6):375-378
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of S100A4 protein in benign and malignant thyroid tissues and its clinical significance. Methods Expression of S100A4 protein in thyroid cancers (50 cases), adenoma (45 cases) and adjacent noncancerous tissue (20 cases) was respectively studied by microwave-LSAB immunohistochemical staining. Results The positive rate of S100A4 protein in thyroid cancer and adenoma was 78.0% and 15.6% respectively. No S100A4 protein expression was found in any adjacent noncancerous tissue (P ＜0. 01). No correlation was observed between expression of S100A4 protein and histological grading of thyroid cancer. Expression of S100A4 protein in lymph node metastasis and staging Ⅲ-Ⅳ was both higher than that in negative cases and staging Ⅰ -Ⅱ (P ＜0. 05). The rate of recurrence and death in S100A4 protein positive cases were notably higher than that in negative cases (P ＜ 0. 05). Conclusions S100A4 protein expression can help to distinguish benign and malignant thyroid tissues. It can be used as a molecular marker to predict thyroid metastasis.