Growth hormone treatment for hypopituitarism after sellar tumor operation

VernacularTitle:生长激素治疗鞍区肿瘤术后垂体功能减低的研究
Author: Liuyang WU ; Gang HUO ; Andong DU ; Lingdang ZHANG ; Qingli FENG ; Maoyuan TANG ; Bo ZHOU
Publication Type:Journal Article
Keywords: Growth hormone; Replacement therapy; Sellar tumor surgery; Hypopituitarism; Life quality
From: Journal of Endocrine Surgery 2012;06(3):166-169
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of growth hormone replacement therapy on life quality of patients with growth hormone deficiency after sellar tumor surgery.Methods The data of 13 patients undergoing sellar tumor resection and suffering postoperative hypopituitarism from Jun.2009 to Dec.2010.were collected.Each of them was given daily 0.5 units growth hormone (about 0.17 mg) as replacement therapy.The life quality of patients at different time points was evaluated with QoL-GDHA scale.SPSS 17.0 software was used for statistical analysis.Results 1,3,and 6 months after treatment,QoL-GDHA score of the patients was 3.91± 2.29,3.38 + 2.43,and 3.23 + 2.28 repectively,significantly lower than before ( 8.69 ± 2.66).The difference had statistical significance (P ＜0.05 ).Conclusion Growth hormone replacement therapy can significantly improve the life quality of patients with hypopituitarism after sellar tumor surgery.